English Setters are not unusually prone to health problems, but there are some inherited diseases that are common in the breed. The most prevalent serious diseases are Hip Dysplasia, Elbow Dysplasia, Deafness, and Hypothyroidism. Good health is especially important in hunting dogs. A hunting dog with hip or elbow problems is almost certainly going to have a shorter career in the field than it should, and likely a shortened life span. More importantly, the dog will have to endure unfair suffering in it's life. A deaf setter is obviously not an ideal hunting companion. It is important for breeders and buyers to be aware of these problems and do their best to lower the incidence in the breed.
Unfortunately taking even the basic step of obtaining an OFA hip certification has been far too slow to catch on among breeders of field English Setters despite the notoriety of Hip Dysplasia. This is not the case in some breeds, like Labrador Retrievers, where it is difficult for a breeder to sell pups unless the parents have OFA and CERF certifications. Buyers have more power to reduce the incidence of inherited diseases than they might think. Becoming informed about the potential problems in the breed they are interested in is the first step. Armed with that knowledge buyers can then ask breeders what health clearances they do, how they are working to reduce these problems, and how often they produce each disease. If breeders become unable to sell puppies without doing the proper health clearances there will likely be a sharp increase in their interest in screening. Below is some basic information about the most common health problems in English Setters, where to find more in depth information, and what Buyers can do to help. By following these guidelines you can maximize your chances of getting a healthy pup and at the same time help reduce the overall incidence of health problems in English Setters.
- Breed normals to normals
- Breed normals with normal ancestry
- Breed normals from litters (brothers/sisters) with a low incidence of HD
Select dogs that have a record of producing a higher percentage of normals than the breed average. Choose replacement dogs that exceed the breed average.It is common to hear people say that using OFA certified dogs hasn't helped reduce HD. This is partially true. Enough progress hasn't been made, and the reason is that many of the breeders who screen for HD are only taking the bare minimum step of following the first recommendation of the OFA- simply certifying their breeding dogs. People naively assume that because a dog has good hips it shouldn't produce HD in it's offspring. When their dog is bred and does produce HD they get angry and blame the OFA method when in fact it is their own ignorance of the importance of following ALL of the guidelines that is to blame. You must know the hip status of a dog's close relatives to have any idea what the real genetic picture is. For instance, an OFA certified dog that has several dysplastic siblings and/or dysplastic parents or grandparents is almost certain to produce a high rate of dysplasia in it's offspring. Breeders following only recommendation #1 are very unlikely to significantly lower the incidence of HD and could easily go backward. We have found that improvement can be dramatic if the other recommendations are also followed, especially #3.
In our experience, selecting breeding dogs whose siblings show little or no evidence of HD is the most important step in reducing HD. A stumbling block is the difficulty in obtaining OFA evaluations from enough of the littermates to be meaningful. Although we had some success early in our breeding program by using dogs that had at least a few normal siblings and no known HD in the background, we found that progress beyond a 10% to 15% overall dysplasia rate was difficult to achieve. Under direct guidance from the OFA we developed a program of requiring preliminary hip evaluations on the puppies we produce. Preliminary OFA's are 80% to 100% accurate in predicting whether a dog will pass a final certification at 2 years, and they give us a very good picture of the hip strength in a litter. They also make it possible to identify litters that have an unacceptable rate of HD so we don't repeat them or use any dogs out of them for breeding. By learning which litters are strong for normal hips, and picking our breeding dogs from them, we have been able to dramatically lower the level of dysplasia. Since 2002 90 pups out of our litters have been submitted to the OFA, for either preliminary evaluations or final certifications, and only 2 of them failed- a rate of 2.2% HD- which is better than we once thought possible. The bottom line is that this approach works, and it has worked for every breeder we know of who has tried a similar program.
October Setters Hip Program An in depth look at our selection process to reduce hip dysplasia, including lists of all OFA results from our litters born between 2002 and 2008.
Although hip dysplasia can virtually always be diagnosed well before breeding age most dysplastic dogs don't show any visible symptoms of the disease until middle age or later, making it too easy for breeders to ignore. Any breeder who says that hip dysplasia is not a problem in English Setters or that he has never had any trouble with it either hasn't x-rayed enough dogs to know, or is not being honest. We highly recommend that you verify the information you are given from breeders (including us) with the OFA. If a dog has an OFA certification you can confirm it with the OFA by phone or through their web site. Unfortunately the OFA does not make all preliminary results available to the public, so you will have to ask to see a copy from the breeder. Buyers can have a strong influence in reducing HD by insisting on buying dogs only from those breeders who follow the OFA recommendations. The best place to research this is the OFA web site, which has extensive information about every dog in the open database, including available data on ancestors, siblings, and offspring. Another very powerful thing owners can do is have their dog evaluated by the OFA whether or not they plan to breed. It is especially important to submit the x-rays of dysplastic dogs and make sure they are in the open database so the results are available to the public. This is the single most effective step buyers can take to force breeders to address the hip problem in setters. We submit all of our dogs to the open database and encourage our customers to do the same.
If you have ever owned a dog that was diagnosed as dysplastic by the OFA you can retroactively have that dog moved to the open database by filling out this form: OFA Change to Open Database Before January 2000 abnormal results were not released to the public, which made it difficult to find out about problems unless breeders were willing to tell you about them. Since then the open database has been optional. We strongly recommend moving all dysplastic dogs into the open database so anyone researching the lines can get a more accurate picture of the hip strength.
PennHIP is an alternative method of evaluating hips that is used by some breeders. It is controversial in the veterinary community and it's validity is not universally accepted. With English Setters it has little practical value for selecting breeding dogs. PennHIP is not a pass/fail screening, and there is no such thing as "PennHIP Certified", or "PennHIP'ed clear" of hip dysplasia. PennHIP only addresses two criteria, (1)laxity and (2)presence or absence of Degenerative Joint Disease (DJD). DJD is arthritic changes to the joint that are the result of Hip Dysplasia. Dogs are given a score called the Distraction Index, or DI, which measures the amount of laxity (also called subluxation) in the hip and compares it to other dogs from the same breed. A score of 0 would mean no laxity, a score of 1 indicates a hip that can be forced completely out of the socket. Based on the dog's DI the report will show where the dog lies in relation to the rest of the breed in the PennHIP database. For instance, a dog in the 90th percentile indicates hips that are in the tightest 10% of the breed. Breeders are told that using breeding dogs that score better than the median score for the breed will decrease the overall incidence of dysplasia. According to PennHIP, a DI of .3 or LESS almost always indicates good hips. Dogs with a DI of .7 or greater virtually always have dysplasia. Also according to PennHIP's research, scores between .4 and .6 are not reliable enough to be useful. Most English Setter scores are higher than .4. PennHIP reports also indicate whether there is any DJD in the hips. Because arthritic changes often take years to develop and there are multiple other aspects of hip joint conformation that can be abnormal, it is entirely possible for a dysplastic dog to have a fairly good looking PennHIP report. An example would be a dog with a middle of the road DI score like .45, which would be better than average for an English Setter, and shows no DJD at the time of evaluation. Some dogs like this will fail an OFA evaluation due to subluxation or one or more of the other abnormalities in the hip joint that PennHIP does not consider. Unfortunately such dogs would also meet PennHIP's breeding criteria. This is a major short coming of the PennHIP method. Unless the hips are very tight, very loose, or arthritic, there is no way to tell from the report whether a dog has good or bad hips. We don't use PennHIP because of this and for the following reasons:
There is no breeding study or data which shows whether selecting for lower DI's decreases the incidence of HD in offspring. The last time we talked to PennHIP they indicated no interest in pursuing a breeding study.
All of the published studies that fully support the PennHIP method were authored or coauthored by Gail Smith, the founder of PennHIP.
Independent studies contradict PennHIP's claims.
PennHIP does not allow independent access to, or review of, it's database.
In English Setters, a breed which has a very high median DI score, simply following PennHIP's recommendation of picking breeding dogs better than the median for the breed would guarantee using a high percentage of dysplastic dogs in a breeding program. Their database also contains only a few hundred English Setters, making the median score relatively meaningless.
Because there is no pass/fail, and because buyers do not understand how PennHIP works, using PennHIP as the ONLY hip screening method gives dishonest breeders a way to hide the fact that they are using dogs in their breeding program that would fail OFA evaluation. This does not mean we believe all breeders who use PennHIP are intentionally dishonest. In fact, a breeder who also has OFA certifications may be especially conscientious. PennHIP DOES NOT, as has sometimes been claimed, do an OFA - like evaluation for anyone, so any "certification" of this type must come from the OFA to be meaningful.
PennHIP's database is fully closed and there is no way to verify DI's for an individual dog.
If you are considering buying a pup from a litter out of parents with PennHIP evaluations and no OFA's, here is what you need to look for: You need to see the actual PennHIP reports for both parents. The DI's of both hips of both parents need to be .3 or less. Both reports must show no DJD present. Both parents should be at least 2 years old. If all of these criteria are met it is very likely the parents of the litter have normal hips.
Deafness Deafness is another common inherited problem in English Setters. Dr. George M. Strain's database of 662 English Setters reports 2.1% totally deaf (both ears) and 10.3% unilaterally deaf (one ear). The English Setter Association of America BAER database, which has more dogs, shows a lower incidence of 5.6% unilateral and 1.3% bilateral. The ESAA database is voluntary so it's possible some deaf dogs are not being reported, which would make the numbers biased toward hearing dogs. Either way a significant number of English Setters are deaf. It occurs in show dogs and all types and lines of field English Setters.
The way English Setters inherit deafness is not clearly understood, but it is related to the white spotting or piebald series of genes in the breed. The piebald genes control the amount of solid dark (black or brown) patching a dog has. These genes cause white spots that cover the underlying black or brown pigment. In English setters the white spotting covers all or most of the dog, typically resulting in either no solid dark patches or only head patches. Ticking comes from a different gene which allows small dots of the underlying black or brown color to show through the white. Deafness related to the white spotting genes is caused by lack of pigment, and subsequent atrophy, of certain structures of the inner ear, which occurs by four weeks of age. Breeds with extreme white piebald genes have a high incidence of deafness- Dalmatians are the poster child breed for this problem. Studies done on Dalmatians show a strong association between deafness and three pigment characteristics that indicate a strong expression of extreme white: lack of solid patches, blue eyes, and missing pigment on the tapetum in one or both eyes. The strongest association is with patching. Although the presence of patches doesn't guarantee a dog can hear, dogs with no solid patches of color have a significantly higher incidence of deafness. Unfortunately data on patching has only been collected for Dalmatians, but according to the leading researcher on the subject there is every reason to expect the same association in English Setters and other breeds that also carry piebald genes. This is supported by the fact that blue eyes have been shown to be associated with deafness in English Setters and English Cocker Spaniels. Some people believe that dogs with missing eyelid pigment or overall light ticking are more likely to be deaf, but studies in Dalmatians have shown no association. The color of the dog- blue, orange, or tricolor, has no relation to deafness.
A common misconception widely circulated in English Setter circles is that lack of patching is not related to deafness in this breed. Although studies in Dalmatians make it clear that selecting for no solid patches is also selecting toward deafness some people still proclaim that patches don't matter in English Setters. There is NO data to back up that belief and anyone who says this has not studied the problem or is ignoring the facts. People don't want to believe that what they consider to be a desirable appearance might be detrimental to the breed, but in this case it is. While the English Setter breed standard doesn't disqualify patched dogs, un-patched competitors are heavily favored, which encourages the selection of dogs with no patching. In Dalmatians patches are not allowed at all. The result is a breed at the extreme white end of the piebald series of genes with a deafness rate of 30%. If the breed clubs wanted to get serious about reducing the incidence of deafness, an effective approach would be to require patching in their breed standards.
There are currently studies underway to try to locate a defective gene that causes deafness. If that gene actually exists a DNA test could be developed to screen for carriers. In the mean time there are two things a breeder can do to reduce the incidence of deafness- select for patches and use dogs with normal hearing.
The hearing status of a breeding dog is an important factor in predicting whether it will produce deafness in it's offspring. Deaf or unilaterally deaf dogs are much more likely to produce deafness than normal hearing dogs are. Many unilaterally deaf, and even some totally deaf dogs, compensate well enough that it is impossible to diagnose the deafness without a hearing (BAER) test. Watching puppies carefully to see if they respond to noises and consistently look the correct direction is helpful, but not foolproof. Bilaterally deaf puppies are obvious when young if you know what to look for but some unis cannot be identified with behavioral tests. Breeders are often unaware they own or have sold deaf dogs, and deafness is often interpreted as the dog being stupid. An old friend of ours who had Rymans all his life used to tell us "They have been great dogs, but every once in a while you get a stupid one that just can't learn anything". These were almost certainly deaf dogs. Buyers should ask breeders if their dogs have been BAER tested and buy pups from parents who have tested normal. Ideally pups should be tested before being sold. Unfortunately there are very few BAER testing centers and for some breeders the closest one is too far to travel with young pups. In that case ask what the breeder does to watch for bilaterally and unilaterally deaf puppies.
This is a simplified explanation of deafness. Anyone who wants to learn more should read the following articles:
http://www.lsu.edu/deafness/VetJDeaf2004.pdf
http://www.lsu.edu/deafness/recent.htm
Elbow Dysplasia Elbow dysplasia (ED) is emerging as a serious problem in English Setters. Currently 16.4% of setters submitted to the OFA have elbow dysplasia. Like hip dysplasia it is a multifaceted, polygenic disease with a complicated inheritance, and is even more likely to cause crippling arthritis and pain. A dog with ED can also sometimes show no visible symptoms until old age, so screening is critical. Reducing the incidence of this disease requires selection of breeding dogs using the same principles that are effective with hip dysplasia. We are aware of only two dogs out of our breedings diagnosed with elbow dysplasia. Our breeding dogs are OFA certified elbows normal.
Hypothyroid English Setters have the highest breed incidence of Autoimmune Thyroiditis, the inherited form of hypothyroidism that causes a dog's immune system to attack the thyroid gland. A dog with Autoimmune Thyroiditis produces antibodies against the thyroid gland that can typically be detected in the blood starting sometime between 2 and 6 years of age. Once a dog is producing these antibodies it usually takes years for the thyroid to be destroyed. Although some dogs will have symptoms of low thyroid at an early age most with the disease will only show signs later in life, and some never do. Some people believe the onset is triggered by infections, vaccines, or other environmental insults that irritate the immune system. One study suggests hypothyroidism is caused by a single recessive gene, but this is not certain. 31.4% of the English Setters Michigan State University has tested through 2007 are positive for thyroid antibodies. The actual percentage of hypothyroid dogs may be even higher- only 50% of the English Setters submitted to the OFA's thyroid database are normal.
The extremely high incidence combined with late onset of the disease make reducing hypothyroidism a daunting challenge in English Setters. With currently available testing it is impossible to eliminate all dogs that carry the genes. Many hypothyroid dogs will be well into their breeding careers before they test positive, and normal dogs that carry the gene may even be past breeding age by the time any of their offspring test positive. Until better testing methods become available progress in English Setters is likely to be very slow.
Although hypothyroidism is not as serious as some of the other inherited diseases, and can be treated effectively and inexpensively with medication, it can cause an incredible array of problems including ear, skin, and coat problems, lethargy, weight gain, reproductive failure, and seizures. It is a good idea to test the thyroid function of all English Setters periodically. The best single screening test available for Autoimmune Thyroiditis is the thyroglobulin autoantibodies test (TgAA). We test our breeding dogs for TgAA through Michigan State University.
For further information regarding these diseases try these links:
- Orthopedic Foundation for Animals Genetic disease registry. Extensive information on hip and elbow dysplasia as well as other inherited diseases. Search database online for OFA certifications. The online breeder's guide and the OFA Overview Guide are must read articles. We highly recommend studying these publications before purchasing a puppy.
- Deafness in Dogs and Cats Dr. Strain's web site on deafness. Dr. Strain is the leading researcher into deafness. Extensive information.
- What’s the Big Deal About the Little Thyroid? Lists the possible symptoms of Hypothyroidism and makes sense of this confusing disease.
- October Setters OFA List A list of our OFA certified dogs.
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